Police are hunting a knifeman who stabbed a shop security guard in the face at the Spar in Piccadilly Gardens in the early hours of Sunday morning.
He then brandished a knife and stabbed a man, aged 29, in the face.
The victim was taken to hospital for treatment to his injuries.
It is understood that the attacker made off after the incident and has not yet been caught.
Detectives are now appealing for witnesses or anyone with information to come forward.
There was a large police presence in the area for several hours after the attack. It was busy with people enjoying a night out.
The area of the store, part of City Tower which faces the Piccadilly bus interchange, was taped off whilst forensic officers carried examinations of the scene, a GMP spokesman said.
Enquiries are ongoing and police are making extensive efforts to identify the man responsible.
Anyone with information is asked to call police on 101 or Crimestoppers, anonymously, on 0800 555 111.
Source – Manchester Evening News